Structure-based membrane dome mechanism for Piezo mechanosensitivity
نویسندگان
چکیده
منابع مشابه
Structure-based membrane dome mechanism for Piezo mechanosensitivity
Mechanosensitive ion channels convert external mechanical stimuli into electrochemical signals for critical processes including touch sensation, balance, and cardiovascular regulation. The best understood mechanosensitive channel, MscL, opens a wide pore, which accounts for mechanosensitive gating due to in-plane area expansion. Eukaryotic Piezo channels have a narrow pore and therefore must ca...
متن کاملMembrane permeable local anesthetics modulate NaV1.5 mechanosensitivity
Voltage-gated sodium selective ion channel Na(V)1.5 is expressed in the heart and the gastrointestinal tract, which are mechanically active organs. Na(V)1.5 is mechanosensitive at stimuli that gate other mechanosensitive ion channels. Local anesthetic and antiarrhythmic drugs act upon Na(V)1.5 to modulate activity by multiple mechanisms. This study examined whether Na(V)1.5 mechanosensitivity i...
متن کاملInsights into a structure-based mechanism of viral membrane fusion.
A number of different viral spike proteins, responsible for membrane fusion, show striking similarities in their core structures. The prospect of developing a general structure-based mechanism seems plausible in light of these newly determined structures. Influenza hemagglutinin (HA) is the best-studied fusion machine, whose action has previously been described by a hypothetical "spring-loaded"...
متن کاملNeuronal mechanism for acute mechanosensitivity in tactile-foraging waterfowl.
Relying almost exclusively on their acute sense of touch, tactile-foraging birds can feed in murky water, but the cellular mechanism is unknown. Mechanical stimuli activate specialized cutaneous end organs in the bill, innervated by trigeminal afferents. We report that trigeminal ganglia (TG) of domestic and wild tactile-foraging ducks exhibit numerical expansion of large-diameter mechanorecept...
متن کاملA piezo‐driven flapping wing mechanism for micro air vehicles
2006). Flapping wing MAVs (FWMAVs) are a class of new conceptual MAVs that take design cues from flying insects in order to achieve a small size (<3–5 cm), high maneuverability and super remote ability (Yan et al. 2015). A FWMAV is expected to work in a variety of confined spaces such as urban canyons, caves, indoors, and jungles that large flying robots can’t be serviceable. To achieve such ta...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: eLife
سال: 2017
ISSN: 2050-084X
DOI: 10.7554/elife.33660